Synthesis and biological activity of 5-oxy-6-bromoindole.
In this study, a new series of N-alkyl-3,6-dibromocarbazole and N-alkyl-5-bromoindole derivatives have been synthesized and evaluated in vitro as anti-cancer and anti-migration agents. Cytotoxic and anti-migratory effects of these compounds were evaluated in MCF-7 and MDA-MB-231 breast cancer cell lines and an insight on the structure-activity relationship was developed. Preliminary.The synthesis of N-alkyl-5-bromoindole derivatives is described in Scheme 2. The 5-bromoindole 28 was reacted with ethyl 4-bromobutyrate, followed by hydrolysis to yield the corresponding 5-bromoindole-4-butyric acid 29. Since N-alkylation in indoles is more difficult than in carbazoles.The Synthesis of 2- and 3-Substituted Indoles Tlabo Caiphus Leboho A dissertation submitted to the Faculty of Science, University of the Witwatersrand, Johannesburg, in fulfilment of the requirement for the degree of Master of Science. January 2008.
A regioselective synthesis of N-carbomethoxy-2,3,5-tribromoindole (6) via a sequential one-pot bromination-aromatization-bromination of N-carbomethoxyindoline (2) is described.Structure, properties, spectra, suppliers and links for: 5-Bromoindole, 10075-50-0.
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